4-(6-bromo-thieno[3,2-b]thiophen-3-yl)-2-(S)-(1-tert-butoxycarbonyl-pyrrolidin-2-yl)-imidazole-1-carboxylic acid tert-butyl ester → HCID 178419471, compound

HRID 716543Notes

Reaction equation

HRID 716543 reaction equation
C(OC([N:8]1[CH:12]=[C:11]([C:13]2[C:14]3[S:20][CH:19]=[C:18]([Br:21])[C:15]=3[S:16][CH:17]=2)[N:10]=[C:9]1[C@@H:22]1[CH2:26][CH2:25][CH2:24][N:23]1C(OC(C)(C)C)=O)=O)(C)(C)C.Cl.BrC1SC2=NC(N)=CN2C=1>>[Br:21][C:18]1[C:15]2[S:16][CH:17]=[C:13]([C:11]3[N:10]=[C:9]([C@@H:22]4[CH2:26][CH2:25][CH2:24][NH:23]4)[NH:8][CH:12]=3)[C:14]=2[S:20][CH:19]=1

Participants

3

Reactant 2

HCID 583103974-(6-bromo-thieno[3,2-b]thiophen-3-yl)-2-(S)-(1-tert-butoxycarbonyl-pyrrolidin-2-yl)-imidazole-1-carboxylic acid tert-butyl esterHCID 672405282-Bromo-imidazo[2,1-b]thiazol-6-ylamine hydrochloride

Product 1

HCID 178419471HCID 178419471, compound

Procedure

Compound 77 was synthesized from compound 76 (1.29 mmol), following the procedure as described for compound 11 to give compound 77 in quantitative yield. MS (ESI, EI+) m/z=354.1/356.13 (MH+).

Sources & evidence

ORD record
ord-c98b5fa41fe24a59924e43cbedd4116b
Source dataset
uspto-grants-2015_11
Patent number
US09187496B2

Reaction notes

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