2-Bromo-imidazo[2,1-b]thiazol-6-ylamine hydrochloride → HCID 178502410, compound

HRID 716545Notes

Reaction equation

HRID 716545 reaction equation
C(OC([N:8]1[CH2:12][CH2:11][CH2:10][CH:9]1[C:13]1[NH:14][C:15]([C:18]2[CH:23]=[CH:22][C:21]([C:24]3[C:25]4[S:31][CH:30]=[C:29]([C:32]5[N:33]=[C:34]([C@@H:37]6[CH2:41][CH2:40][CH2:39][N:38]6[C:42](=[O:52])[C@@H:43]([NH:47][C:48]([O:50][CH3:51])=[O:49])[CH:44]([CH3:46])[CH3:45])[NH:35][CH:36]=5)[C:26]=4[S:27][CH:28]=3)=[CH:20][CH:19]=2)=[CH:16][N:17]=1)=O)(C)(C)C.[ClH:53].BrC1SC2=NC(N)=CN2C=1>>[ClH:53].[CH3:51][O:50][C:48](=[O:49])[NH:47][C@H:43]([C:42]([N:38]1[CH2:39][CH2:40][CH2:41][C@H:37]1[C:34]1[NH:35][CH:36]=[C:32]([C:29]2[C:26]3[S:27][CH:28]=[C:24]([C:21]4[CH:22]=[CH:23][C:18]([C:15]5[NH:14][C:13]([C@@H:9]6[CH2:10][CH2:11][CH2:12][NH:8]6)=[N:17][CH:16]=5)=[CH:19][CH:20]=4)[C:25]=3[S:31][CH:30]=2)[N:33]=1)=[O:52])[CH:44]([CH3:46])[CH3:45]

Participants

3

Reactant 2

HCID 672405282-Bromo-imidazo[2,1-b]thiazol-6-ylamine hydrochlorideHCID 178502409HCID 178502409, compound

Product 1

HCID 178502410HCID 178502410, compound

Procedure

Compound 80 was synthesized from compound 79 (1.36 mmol), following the procedure as described for compound 11 to give compound 80 in quantitative yield. MS (ESI, EI+) m/z=645.2 (MH+).

Sources & evidence

ORD record
ord-b29671a8917b43618971927fac854525
Source dataset
uspto-grants-2015_11
Patent number
US09187496B2

Reaction notes

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