Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | Diethylamine | HCID 8021 | — |
| Reactant | Iodobenzene | HCID 11575 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | N,N-Dimethylethylenediamine | HCID 66053 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | HCID 86719464 | HCID 86719464 | — |
Reaction Steps
An exemplary process to form a triazole product may include reacting calcium carbide, benzaldehyde, diethylamine, CuI and CH3CN for 18 hours at 80° C. (AAA-coupling), followed by addition of sodium azide, iodobenzene, CuI and N,N-dimethylethylenediamine in dimethyl formamide and stirred for 12 hours at 40° C. to obtain N-ethyl-N-(phenyl(1-phenyl-1H-1,2,3-triazol-4-yl)methyl)ethanamine after extraction and purification with 84% isolated yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09193668B2 |
|---|
| Source dataset | uspto-grants-2015_11 |
|---|
| ORD ID | ord-b07395077c3649b9ba455790d5cd4818 |
|---|
| Source note | uspto-grants-2015_11 |
|---|
