関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Carbon Tetrachloride | HCID 5943 | — |
| 反応物 | N-bromobutanimide | HCID 67184 | — |
| 反応物 | 2-Bromo-5-methylpyridine | HCID 564216 | — |
| 触媒 | Benzoyl Peroxide | HCID 7187 | — |
| 生成物 | 2-Bromo-5-bromomethylpyridine | HCID 6424660 | 105.4% |
反応手順
To a solution of 2-Bromo-5-methylpyridine (3.1 g, 17.4 mmol) in carbon tetrachloride (40 mL, 400 mmol) was added benzoyl peroxide (230 mg, 950 μmol) and NBS (3.4 g, 19.2 mmol). The resulting mixture was heated at reflux overnight. The mixture was cooled at 0° C. and the NBS was removed by filtration. The filtrate was concentrated to yield 2-bromo-5-bromomethylpyridine (4.6 g), which was used directly in the next step.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08822522B2 |
|---|
| 出典データセット | uspto-grants-2014_09 |
|---|
| ORD ID | ord-cef9ca7e4a984936b559bd23095e3b06 |
|---|
| 出典メモ | uspto-grants-2014_09 |
|---|
