HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Malonate → Ethyl 4-hydroxy-1-(isoprenyl)-2-oxo-1,2-dihydroquinoline-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Malonate | HCID 7761 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | N-isoprenyl isatoic anhydride | HCID 131734149 | — |
| Product | Ethyl 4-hydroxy-1-(isoprenyl)-2-oxo-1,2-dihydroquinoline-3-carboxylate | HCID 131734150 | — |
Reaction Steps
Reagents: Comp 18 (1.3 mmols, 0.3 g); Sodium hydride (1.3 mmols, 0.065 g); Diethyl malonate (6.5 mmols, 1.0 g). Yield: 0.08 g (21%), white solid, m.p.=123° C.-124° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193688B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-7989c77f1bc140f9b058d13041caa0ab |
| Source note | uspto-grants-2015_11 |