HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diethyl Malonate → 3-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-(2-methylpropyl)-2-oxo-, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diethyl Malonate | HCID 7761 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | 1-(2-methylpropyl)-2,4-dihydro-1H-3,1-benzoxazine-2,4-dione | HCID 3578689 | — |
| Product | 3-Quinolinecarboxylic acid, 1,2-dihydro-4-hydroxy-1-(2-methylpropyl)-2-oxo-, ethyl ester | HCID 69398311 | — |
Reaction Steps
Reagents: Comp 19 (1.36 mmols, 0.3 g); Sodium hydride (5.75 mmols, 0.138 g); Diethyl malonate (6.84 mmols, 1.1 g). Yield: 0.15 g (38%), yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193688B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-783626b20a934ebd9ee5eb5f87276e3d |
| Source note | uspto-grants-2015_11 |