4-Nitrophenethyl alcohol → HCID 12942079, compound

Participants

Reaction Steps

Under a nitrogen atmosphere, MsCl (13.9 mL) was dropwise added to a suspension of 2-(4-nitrophenyl)ethanol (25.0 g) and Et3N (31.3 mL) in CHCl3 (including amylene, 625 mL) over 10 minutes under ice cooling, followed by stirring at room temperature for 2 hours. A saturated aqueous NaHCO3 solution was added to the reaction solution, and the aqueous layer was extracted with CHCl3. The combined organic layer was dried over MgSO4, and then the desiccant was removed by filtration. The filtrate was concentrated under reduced pressure to yield the title compound (41.8 g, light yellow solid).

Provenance & Evidence