Butane-2-sulfonyl chloride → Tert-butyl 2-(3-(1-methylpropylsulfonamido)phenoxy)ethylcarbamate

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Reaction Steps

Sulfonation of tert-butyl 2-(3-aminophenoxy)ethylcarbamate (3) using butane-2-sulfonyl chloride following the method described in Example 1 gave tert-butyl 2-(3-(1-methylpropylsulfonamido)phenoxy)ethylcarbamate (6) as a light yellow oil. 1H NMR (400 MHz, DMSO-d6) δ 9.72 (s, 1H), 7.17 (t, J=8.0 Hz, 1H), 6.97 (t, J=6.0 Hz, 1H), 6.76-6.78 (m, 2H), 6.59-6.62 (m, 1H), 3.87 (t, J=5.6 Hz, 2H), 3.24 (q, J=6.4 Hz, 2H), 2.93-3.02 (m, 1H), 1.80-1.91 (m, 1H), 1.40-1.48 (m, 1H), 1.35 (s, 9H), 1.19 (d, J=6.8 Hz, 3H), 0.88 (t, J=7.2 Hz, 3H).

Provenance & Evidence