HCID 67296450, compound → HCID 67313802, compound

Participants

Reaction Steps

Oxidation of tert-butyl 3-(3-(cyclohexanecarboxamido)phenyl)-3-hydroxypropylcarbamate (37) following the method used in Example 12 except PCC was used in lieu of MnO2 gave tert-butyl 3-(3-(cyclohexanecarboxamido)phenyl)-3-oxopropylcarbamate as a white solid. Yield (0.36 g, 91%); 1H NMR (400 MHz, DMSO-d6) δ 9.97 (s, 1H), 8.15-8.18 (m, 1H), 7.82 (dd, J=1.2, 8.0 Hz, 1H), 7.57 (d, J=8.0 Hz, 1H), 7.40 (t, J=8.0 Hz, 1H), 6.79 (br.t, 1H), 3.24 (q, J=6.0 Hz, 2H), 3.08 (t, J=6.4 Hz, 2H), 2.25-2.35 (m, 1H), 1.69-1.82 (m, 4H), 1.58-1.66 (m, 1H), 1.33 (s, 9H), 1.10-1.44 (m, 5H).

Provenance & Evidence