Sodium Bicarbonate → HCID 71090374, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of tert-butyl N-[(1R)-1-[[6-[(3,3-dimethyl-1H-isobenzofuran-5-yl)oxy]-3-pyridyl]carbamoyl]propyl]carbamate (Intermediate 53, 25 mg, 0.0566 mmol) in DCM (2 mL) 2,2,2-trifluoroacetic acid (0.5 ml, 6.53 mmol) was added and the reaction mixture was stirred for 3 hours at 0° C. The reaction was diluted with DCM (10 ml) and an aqueous saturated solution of NaHCO3 was added while the pH was allowed to reach ˜8. Two phases were separated and the organic layer was dried (Na2SO4), filtered and evaporated to afford the title compound (18 mg) as white solid.

Provenance & Evidence