Potassium Carbonate → HCID 71113151, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (5R)-5-ethyl-3-(6-fluoro-5-methyl-3-pyridyl)-5-methyl-imidazolidine-2,4-dione (Intermediate 5, 48 mg, 0.19 mmol) in DMF (1 ml) 3,3-dimethyl-1H-isobenzofuran-5-ol (Intermediate 18, 45 mg, 0.27 mmol) and dipotassium carbonate (75.7 mg, 0.55 mmol) were added and the reaction mixture was stirred at 110° C. for 10 hours. The reaction was quenched with an aqueous saturated solution of ammonium chloride (5 ml) and extracted with ethyl acetate (10 ml). The organic layer was washed with brine (3×10 ml) dried over sodium sulphate and concentrated under vacuum. The residue was purified by flash chromatography on silica gel (Biotage system) using a SNAP 10 g as column and cyclohexane/ethyl acetate from 85:15 to 20:80 as eluent to afford the title compound (20 mg) as white solid.

Provenance & Evidence