Purine → HCID 178420486, compound

Participants

Reaction Steps

The general procedure for the synthesis of purine derivatives is depicted in FIG. 1. The initial compound 6-chloropurine (1.0 eq.) was mixed with aniline (1.20 eq.) and K2CO3 (2.5 eq.) in 50.0 ml dioxane. The resultant mixture was charged in 100 mL round bottom flask with a stirring bar. The mixture was refluxed overnight and monitored by TLC. After the reaction finished, the solvent was removed and the remaining residue was extracted by ethyl acetate. After removing the solvent, the resultant crude product was purified by silica gel column chromatography eluting with CH2Cl2/MeOH (5%) to provide pure titled compound.

Provenance & Evidence