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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 717053Generated: October 31, 2026

Picolyl chloride hydrochloride → 7-(2-tert-butoxypyridin-4-yl)-4-(pyridin-2-ylmethyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one

https://huagongshe.com/reaction/717053

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPicolyl chloride hydrochlorideHCID 23392—
Reactant2-(tert-Butoxy)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridineHCID 45785993—
Reactant7-Bromo-2,3,4,5-tetrahydro-1,4-benzoxazepin-5-oneHCID 60124972—
Product7-(2-tert-butoxypyridin-4-yl)-4-(pyridin-2-ylmethyl)-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-oneHCID 71183721—

Reaction Steps

Compound VI-4 was prepared according to Example 36 using 7-bromo-3,4-dihydrobenzo[f][1,4]oxazepin-5(2H)-one, 2-tert-butoxy-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine and 2-(chloromethyl)pyridine hydrochloride.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09193694B2
Source datasetuspto-grants-2015_11
ORD IDord-cc9bbba5e6bc409ab6256eaa570c2677
Source noteuspto-grants-2015_11