Hydrochloric Acid → HCID 71737241, compound

Participants

Reaction Steps

To a stirred solution of 3-{4-[4-(tert-butyl-diphenyl-silanyloxy)-piperidin-1-ylmethyl]-phenyl}-5-methyl-2H-isoquinolin-1-one (213 mg, 0.36 mmol) in CH2Cl2 (2 mL) was added 1.25M methanolic HCl (1 mL) and the reaction stirred at RT for 48 h. The reaction mixture was concentrated in vacuo and the crude residue purified by reverse phase preparative HPLC-MS to afford 3-[4-(4-hydroxy-piperidin-1-ylmethyl)-phenyl]-5-methyl-2H-isoquinolin-1-one as a pale yellow solid (80 mg, 64%).

Provenance & Evidence