Hydrazine → HCID 178419360, compound

HRID 717204Notes

Reaction equation

HRID 717204 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8](/[N:10]=[CH:11]/[N:12](C)C)=O)=[N:6][CH:7]=1.[NH2:15]N>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:10]=[CH:11][NH:12][N:15]=2)=[N:6][CH:7]=1

Participants

3

Reactant 2

HCID 9321HydrazineHCID 178484325HCID 178484325, compound

Product 1

HCID 178419360HCID 178419360, compoundYield 83.2%

Procedure

A solution of (E)-5-bromo-N-((dimethylamino)methylene)picolinamide (0.604 mg, 2.36 mmol) and hydrazine (2.12 g, 66.1 mmol) was stirred at 25° C. for 3 h. The reaction was concentrated and diluted with water. The resulting precipitate was collected by filtration and dried under vacuum to give the title compound (0.442 g, 83% yield). MS (ESI) m/z 226.1 [M+1]+.

Workup

  1. concentrationThe reaction was concentrated
  2. additiondiluted with water
  3. filtrationThe resulting precipitate was collected by filtration
  4. customdried under vacuum

Sources & evidence

ORD record
ord-7886a2ffd1f14f6f8eb29e6f51bdcb50
Source dataset
uspto-grants-2015_11
Patent number
US09193692B2

Reaction notes

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