Pentanenitrile, 4,4-dimethyl-3-oxo- → HCID 67546777, compound

HRID 717231Notes

Reaction equation

HRID 717231 reaction equation
[O:1]1[CH2:5][CH2:4][CH2:3][C@H:2]1[CH2:6][NH:7][NH2:8].[CH3:9][C:10]([CH3:17])([CH3:16])[C:11](=O)[CH2:12][C:13]#[N:14]>C(O)C>[C:10]([C:11]1[CH:12]=[C:13]([NH2:14])[N:7]([CH2:6][C@@H:2]2[CH2:3][CH2:4][CH2:5][O:1]2)[N:8]=1)([CH3:17])([CH3:16])[CH3:9]

Participants

4

Reactant 2

HCID 108871Pentanenitrile, 4,4-dimethyl-3-oxo-HCID 28084058HCID 28084058, compound

Product 1

HCID 67546777HCID 67546777, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a stirred solution of the product from Example 12B (232 mg, 2.0 mmol) in ethanol (4 mL) was added 4,4-dimethyl-3-oxopentanenitrile (250 mg, 2.0 mmol). The mixture was refluxed for 2 hours. The ethanol was removed by evaporation under reduced pressure and the crude product was dissolved in CH2Cl2 (10 mL), which was used directly for the next step.

Workup

  1. temperatureThe mixture was refluxed for 2 hours
  2. customThe ethanol was removed by evaporation under reduced pressure
  3. dissolutionthe crude product was dissolved in CH2Cl2 (10 mL)

Sources & evidence

ORD record
ord-df5324e9c6814466bf1fa3fb25fb5cc7
Source dataset
uspto-grants-2015_11
Patent number
US09193713B2

Reaction notes

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