反应详情

温度

90 °C

A mixture of 2-ethoxy-5-(trifluoromethyl)benzoic acid (0.20 g, 0.84 mmol) and SOCl2 (5 mL) was warmed to 90° C. for 2 h and then was cooled to ambient temperature and concentrated under reduced pressure. The crude material was diluted with 10 mL toluene and was concentrated again. This dilution/concentration was repeated two additional times to provide 2-ethoxy-5-(trifluoromethyl)benzoyl chloride, that was used directly below.

1. temperaturewas cooled to ambient temperature
2. concentrationconcentrated under reduced pressure
3. additionThe crude material was diluted with 10 mL toluene
4. concentrationwas concentrated again
5. concentrationThis dilution/concentration