Potassium Phosphate, Tribasic → HCID 178461687, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of (5R)-5-benzyl-5-(5-bromo-1H-benzimidazol-2-yl)-3-[(1R)-1-(4-fluorophenyl)ethyl]-1,3-oxazolidine-2,4-dione (25 mg), Pd(OAc)2 (1 mg), dppf (5.5 mg), K3PO4 (31 mg), 3-pyrimidinyl boronic acid (12 mg) in 0.5 mL of ethanol was heated at 120° C. in microwave for 5 min. The reaction mixture was diluted with EtOAc, filtered, concentrated, and then purified via Gilson RP-HPLC (30-100% MeCN/water w/0.1% TFA) to give the title compound. LC/MS 508.1 (M+1). IC50 value=A rating

Provenance & Evidence