HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → Diethylamino(benzyl)propanedioate trifluoroacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Diethyl 2-benzyl-2-(tert-butoxycarbonylamino)malonate | HCID 59685129 | — |
| Product | Diethylamino(benzyl)propanedioate trifluoroacetate | HCID 89500110 | — |
Reaction Steps
To the product of Step A (7.5 g, 20.52 mmol) in dichloromethane (24 mL) was added trifluoroacetic acid (12 mL, 156 mmol) and the mixture stirred for 1 h. The solvent was removed in vacuo and the oil azeotroped with toluene (2×20 mL) to afford the title compound as a tan amorphous solid. LC/MS 266.1 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193717B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-ad7daaaed6774a9a9d9a229c510b17fb |
| Source note | uspto-grants-2015_11 |