HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → HCID 90396916, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | N-(3,4-diaminophenyl)methanesulfonamide | HCID 12709656 | — |
| Reactant | HCID 89500113 | HCID 89500113 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 90396916 | HCID 90396916 | — |
Reaction Steps
A mixture of (R)-3-ethoxy-2-(4-fluorobenzyl)-2-hydroxy-3-oxopropanoic acid (1.28 g, 5 mmol), HATU (1.9 g 5 mmol), N-(3,4-diaminophenyl) methanesulfonamide (1 g, 5 mmol) in 4 mL of DMF was stirred at rt overnight. To this mixture was added water (20 ml) and ethyl acetate (50 ml). The organic layer was separated and washed with water (10 ml) and then concentrated in vacuo after being dried over anhydrous MgSO4. The residue was purified by PREP-HPLC to give the product as white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193717B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-3dbd129901e849be9020633b7bf59234 |
| Source note | uspto-grants-2015_11 |