反应详情

Into a 500-mL round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed a mixture of 5-fluoro-2-nitrobenzamide (17.5 g, 95.04 mmol, 1.00 equiv) and palladium carbon (10%) (1.75 g, 0.10 equiv) in methanol (150 mL). To the above H2 (enough) was introduced. The resulting solution was stirred for 2 h at room temperature. The solids were filtered out. The resulting mixture was concentrated under vacuum. This resulted in 12.0 g (82%) of 2-amino-5-fluorobenzamide as a white solid. MS (ESI) m/z 155 ([M+H]+).

1. customInto a 500-mL round-bottom flask purged
2. temperaturemaintained with an inert atmosphere of nitrogen
3. additionTo the above H2 (enough) was introduced
4. filtrationThe solids were filtered out
5. concentrationThe resulting mixture was concentrated under vacuum
6. customThis resulted in 12.0 g (82%) of 2-amino-5-fluorobenzamide as a white solid