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HRID 717395作成日：2026年10月27日

6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride → 2-[[2-(4-Fluorophenyl)quinazolin-4-yl]carbonyl]-6-methoxy-1,2,3,4-tetrahydroisoquinoline

https://huagongshe.com/reaction/717395

反応式

関与物質

役割名称HCID仕込み量
反応物6-Methoxy-1,2,3,4-tetrahydroisoquinoline hydrochlorideHCID 2920335—
反応物2-(4-Fluorophenyl)quinazoline-4-carboxylic acidHCID 90411497—
生成物2-[[2-(4-Fluorophenyl)quinazolin-4-yl]carbonyl]-6-methoxy-1,2,3,4-tetrahydroisoquinolineHCID 9041035723.5%

反応手順

Reaction of 2-(4-fluorophenyl)quinazoline-4-carboxylic acid with 6-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride gave compound 7 (23.5% yield): 1H NMR (400 MHz, CDCl3) δ 2.87 and 3.11 (2t, 2H), 3.58 and 4.19 (2t, 2H), 3.81 and 3.84 (2s, 3H), 4.47 and 5.08 (2s, 2H), 6.68-6.90 (m, 2H), 7.20-7.25 (m, 3H), 7.57-7.66 (m, 1H), 7.93-8.06 (m, 2H), 8.19-8.21 (d, 8.65-8.71 (m, 2H); 19F (282 MHz, CDCl3) δ −109.5; MS (ESI) m/z 414 ([M+H]+).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US09193707B2
出典データセットuspto-grants-2015_11
ORD IDord-7ef1c2fadc0f4d359683e367d1a9cf8e
出典メモuspto-grants-2015_11