5-Fluoro-1,2,3,4-tetrahydroisoquinoline--hydrogen chloride (1/1) → HCID 90410954, compound

Participants

Reaction Steps

Reaction of 2-(4-fluorophenyl)quinazoline-4-carboxylic acid with 5-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride gave compound 10 (27.0% yield) as a white solid. 1H NMR (400 MHz, CDCl3) δ 2.88 and 3.13 (2t, 2H), 3.64 and 4.24 (2t, 2H), 4.58 and 5.14 (2s, 2H), 6.68-7.33 (m, 5H), 7.65-7.77 (m, 1H), 7.94-8.10 (m, 2H), 8.15-8.20 (m, 1H), 8.57-8.67 (m, 2H); 19F (282 MHz, DMSO-d6) δ −112.0, −121.0; MS (ESI) m/z 402 ([M+H]+).

Provenance & Evidence