HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Fluoro-2-(3,4,5-trimethoxyphenyl)quinazoline-4-carboxylic acid → 2-[[6-Fluoro-2-(3,4,5-trimethoxyphenyl)quinazolin-4-yl]carbonyl]-5,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Fluoro-2-(3,4,5-trimethoxyphenyl)quinazoline-4-carboxylic acid | HCID 90410307 | — |
| Reactant | 5,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride | HCID 90411806 | — |
| Product | 2-[[6-Fluoro-2-(3,4,5-trimethoxyphenyl)quinazolin-4-yl]carbonyl]-5,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline | HCID 86268405 | 34.3% |
Reaction Steps
Reaction of 6-fluoro-2-(3,4,5-trimethoxyphenyl)quinazoline-4-carboxylic acid with 5,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride gave compound 106 (34.3% yield). 1H NMR (300 MHz, DMSO-d6) δ 2.84 and 2.99 (2t, 2H), 3.48 (s, 1H), 3.53 and 4.03 (2t, 2H), 3.69-3.3.81 (m, 6H), 3.86-3.92 (m, 8H), 4.31 and 4.77 (2s, 2H), 6.35-6.50 (m, 2H), 7.66-7.85 (m, 3H), 8.02-8.05 (m, 1H), 8.23-8.28 (m, 1H); MS (ESI) m/z 534 ([M+H]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193707B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-8f6ba8a43a3a44c7bf966a3bb7650eab |
| Source note | uspto-grants-2015_11 |