HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride → 2-[[6-Fluoro-2-(3,4,5-trimethoxyphenyl)quinazolin-4-yl]carbonyl]-6-fluoro-1,2,3,4-tetrahydroisoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride | HCID 45074042 | — |
| Reactant | 6-Fluoro-2-(3,4,5-trimethoxyphenyl)quinazoline-4-carboxylic acid | HCID 90410307 | — |
| Product | 2-[[6-Fluoro-2-(3,4,5-trimethoxyphenyl)quinazolin-4-yl]carbonyl]-6-fluoro-1,2,3,4-tetrahydroisoquinoline | HCID 86268607 | 54.3% |
Reaction Steps
Reaction of 6-fluoro-2-(3,4,5-trimethoxyphenyl)quinazoline-4-carboxylic acid with 6-fluoro-1,2,3,4-tetrahydroisoquinoline hydrochloride gave compound 108 (54.3% yield). 1H NMR (300 MHz, DMSO-d6) δ 2.92 and 3.07 (2t, 2H), 3.58 and 4.04 (2t, 2H), 3.76-3.3.77 (d, 3H), 3.86 and 3.91 (2s, 6H), 4.55 and 4.98 (2s, 2H), 6.95-7.41 (m, 3H), 7.65-7.85 (m, 3H), 7.99-8.05 (m, 1H), 8.23-8.28 (m, 1H); MS (ESI) m/z 492 ([M+H]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193707B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-6f09712c43bf4e41833511805224c94d |
| Source note | uspto-grants-2015_11 |