HuagongsheHuagongshe Chemistry Print Report · For research reference only
6,7-Dimethoxy-2-(4-fluorophenyl)quinazoline-4-carboxylic acid → 2-[[6,7-Dimethoxy-2-(4-fluorophenyl)quinazolin-4-yl]carbonyl]-5-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6,7-Dimethoxy-2-(4-fluorophenyl)quinazoline-4-carboxylic acid | HCID 90410706 | — |
| Reactant | 6-Methoxy-1,2,3,4-tetrahydroisoquinolin-5-ol hydrochloride | HCID 90411180 | — |
| Product | 2-[[6,7-Dimethoxy-2-(4-fluorophenyl)quinazolin-4-yl]carbonyl]-5-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline | HCID 86268408 | 18% |
Reaction Steps
Reaction of 6,7-dimethoxy-2-(4-fluorophenyl)quinazoline-4-carboxylic acid with 5-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride gave compound 109 (18.0% yield). 1H NMR (300 MHz, DMSO-d6) δ 2.67 and 2.92 (2t, 2H), 3.45-4.06 (m, 11H), 4.37 and 4.90 (2s, 2H), 6.27-7.11 (m, 3H), 7.36-7.42 (m, 1H), 7.50-7.65 (m, 2H), 8.12-8.20 (m, 1H), 8.29-8.35 (m, 1H), 8.68 and 8.73 (2s, 1H); MS (ESI) m/z 490 ([M+H]+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193707B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-71f0843c61614f60994cb360756d73d0 |
| Source note | uspto-grants-2015_11 |