HRID717488

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：COc1cc2nc(-c3cc(OC)c(OC)c(OC)c3)nc(C(=O)O)c2cc1OC

HCID90410640

未命名化合物

HCID90411180

未命名化合物

PRODUCTS

生成物

结构：COc1cc2nc(-c3cc(OC)c(OC)c(OC)c3)nc(C(=O)N3CCc4c(ccc(OC)c4O)C3)c2cc1OC

HCID90411142

未命名化合物

收率 13.6%

PROCEDURE

实验过程

Reaction of 6,7-dimethoxy-2-(3,4,5-trimethoxyphenyl)quinazoline-4-carboxylic acid with 5-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinoline hydrochloride gave compound 115 (13.6% yield). 1H NMR (300 MHz, DMSO-d6) δ 2.83 and 2.90 (2t, 2H), 3.49-4.05 (m, 20H), 4.37 and 4.90 (2s, 2H), 6.27-7.16 (m, 3H), 7.46 and 7.50 (2s, 1H), 7.78 and 7.84 (2s, 2H), 8.70 and 8.73 (2s, 1H); MS (ESI) m/z 562 ([M+H]+).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8712cd5330e34bf8bf2b690e17882f6b
来源数据集: uspto-grants-2015_11
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09193707B2
来源说明: uspto-grants-2015_11

反应 SMILES

[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[C:8]([C:15]1[CH:20]=[C:19]([O:21][CH3:22])[C:18]([O:23][CH3:24])=[C:17]([O:25][CH3:26])[CH:16]=1)[N:7]=[C:6]2[C:27]([OH:29])=O.Cl.[OH:31][C:32]1[C:41]([O:42][CH3:43])=[CH:40][CH:39]=[C:38]2[C:33]=1[CH2:34][CH2:35][NH:36][CH2:37]2>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][C:12]=1[O:13][CH3:14])[N:9]=[C:8]([C:15]1[CH:16]=[C:17]([O:25][CH3:26])[C:18]([O:23][CH3:24])=[C:19]([O:21][CH3:22])[CH:20]=1)[N:7]=[C:6]2[C:27]([N:36]1[CH2:35][CH2:34][C:33]2[C:38](=[CH:39][CH:40]=[C:41]([O:42][CH3:43])[C:32]=2[OH:31])[CH2:37]1)=[O:29]