HCID 71284096, compound → HCID 71284243, compound

HRID 717520Notes

Reaction equation

HRID 717520 reaction equation
Cl[C:2]1[CH:7]=[C:6]([C:8]2[CH2:14][C:13](=[O:15])[NH:12][C:11]3[CH:16]=[C:17]([C:20]([NH:22][CH2:23][C:24]#[CH:25])=[O:21])[CH:18]=[CH:19][C:10]=3[N:9]=2)[CH:5]=[CH:4][N:3]=1.[C:26](C1C=C(C2CC(=O)NC3C=C(C(NCC#C)=O)C=CC=3N=2)C=CN=1)#[N:27].C(C1C=C(C2CC(=O)NC3C=C(B(O)O)C=CC=3N=2)C=CC=1)#N.C(C1C=C(C2CC(=O)NC3C=C(C(=N)N)C=CC=3N=2)C=CC=1)#N.C(C1C=C(C2CC(=O)NC3C=C(C(=N)NC(=O)C)C=CC=3N=2)C=CC=1)#N.O=C1NC2C=C(C(N)=O)C=CC=2N=C(C2C=CN=NC=2)C1.O=C1NC2C=C(C(NCCC)=O)C=CC=2N=C(C2C=CN=NC=2)C1.C(NC(C1C=CC2N=C(C3C=CN=NC=3)CC(=O)NC=2C=1)=O)C=C>>[C:26]([C:2]1[CH:7]=[C:6]([C:8]2[CH2:14][C:13](=[O:15])[NH:12][C:11]3[CH:16]=[C:17]([C:20]([NH:22][CH2:23][CH2:24][CH3:25])=[O:21])[CH:18]=[CH:19][C:10]=3[N:9]=2)[CH:5]=[CH:4][N:3]=1)#[N:27]

Participants

9

Reactant 8

HCID 71284096HCID 71284096, compound2×HCID 71509653HCID 71509653, compound2×HCID 71509654HCID 71509654, compound2×HCID 71509655HCID 71509655, compound2×HCID 71509793HCID 71509793, compound2×HCID 71509794HCID 71509794, compound2×HCID 71509795HCID 71509795, compound2×HCID 140664583HCID 140664583, compound2×

Product 1

HCID 71284243HCID 71284243, compound

Procedure

4-(2-Chloropyridin-4-yl)-2-oxo-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-benzo[b][1,4]diazepine-8-carboxamide (Compound 69); 4-(2-Cyanopyridin-4-yl)-2-oxo-N-(prop-2-yn-1-yl)-2,3-dihydro-1H-benzo[b][1,4]diazepine-8-carboxamide (Compound 70); (4-(3-Cyanophenyl)-2-oxo-2,3-dihydro-1H-benzo[b][1,4]diazepin-8-yl)boronic acid (Compound 71); 4-(3-Cyanophenyl)-2-oxo-2,3-dihydro-1H-benzo[b][1,4]diazepine-8-carboximidamide (Compound 72); N-((4-(3-Cyanophenyl)-2-oxo-2,3-dihydro-1H-benzo[b][1,4]diazepin-8-yl)(imino)methyl)-acetamide (Compound 73); 2-Oxo-4-(pyridazin-4-yl)-2,3-dihydro-1H-benzo[b][1,4]diazepine-8-carboxamide (Compound 74); 2-oxo-N-propyl-4-(pyridazin-4-yl)-2,3-dihydro-1H-benzo[b][1,4]diazepine-8-carboxamide (Compound 75); N-Allyl-2-oxo-4-(pyridazin-4-yl)-2,3-dihydro-1H-benzo[b][1,4]diazepine-8-carboxamide (Compound 76).

Sources & evidence

ORD record
ord-d6806efe25d0403188774eb7765d28f6
Source dataset
uspto-grants-2015_11
Patent number
US09193710B2

Reaction notes

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