2-Thiopheneboronic acid → HCID 71284204, compound

HRID 717532Notes

Reaction equation

HRID 717532 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][N:15]=[N:14][CH:13]=3)[CH2:9][C:8](=[O:18])[NH:7][C:6]=2[CH:19]=1.[S:20]1[CH:24]=[CH:23][CH:22]=[C:21]1B(O)O>>[S:20]1[CH:24]=[CH:23][CH:22]=[C:21]1[C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][N:15]=[N:14][CH:13]=3)[CH2:9][C:8](=[O:18])[NH:7][C:6]=2[CH:19]=1

Participants

3

Reactant 2

HCID 27339602-Thiopheneboronic acidHCID 71284108HCID 71284108, compound

Product 1

HCID 71284204HCID 71284204, compound

Procedure

The title compound was prepared from 8-bromo-4-(pyridazin-4-yl)-1H-benzo[b][1,4]diazepin-2(3H)-one (Example 1; 1 mmol) and commercial available thiophene-2-boronic acid (CAS-No: 6165-68-0)) (1.5 mmol) according to the general procedure G. Obtained as a yellow solid (51%), MS (EI) 321 [(M+1)+].

Sources & evidence

ORD record
ord-cc4ab2d8aa134cca8e6a977c379490de
Source dataset
uspto-grants-2015_11
Patent number
US09193710B2

Reaction notes

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