3,4-Dimethoxyphenylboronic acid → HCID 71284269, compound

HRID 717534Notes

Reaction equation

HRID 717534 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[N:11]=[C:10]([C:12]3[CH:17]=[CH:16][N:15]=[N:14][CH:13]=3)[CH2:9][C:8](=[O:18])[NH:7][C:6]=2[CH:19]=1.[CH3:20][O:21][C:22]1[CH:23]=[C:24](B(O)O)[CH:25]=[CH:26][C:27]=1[O:28][CH3:29]>>[CH3:20][O:21][C:22]1[CH:23]=[C:24]([C:2]2[CH:3]=[CH:4][C:5]3[N:11]=[C:10]([C:12]4[CH:17]=[CH:16][N:15]=[N:14][CH:13]=4)[CH2:9][C:8](=[O:18])[NH:7][C:6]=3[CH:19]=2)[CH:25]=[CH:26][C:27]=1[O:28][CH3:29]

Participants

3

Reactant 2

HCID 27347023,4-Dimethoxyphenylboronic acidHCID 71284108HCID 71284108, compound

Product 1

HCID 71284269HCID 71284269, compound

Procedure

The title compound was prepared from 8-bromo-4-(pyridazin-4-yl)-1H-benzo[b][1,4]diazepin-2(3H)-one (Example 1; 1 mmol) and commercial available 3,4-dimethoxyphenylboronic acid (CAS-No: 122775-35-3; 1.5 mmol) according to the general procedure G. Obtained as a yellow solid (75%), MS (EI) 375 [(M+1)+].

Sources & evidence

ORD record
ord-85bc6b59fc7349758614ff971d428df9
Source dataset
uspto-grants-2015_11
Patent number
US09193710B2

Reaction notes

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