HCID 178426513, compound → HCID 82566418, compound

HRID 717558Notes

Reaction equation

HRID 717558 reaction equation
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:17]=1)[C:7](=[NH:16])[NH:8][C:9]1[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][N:10]=1>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:17]=[C:6]([C:7]2[N:8]=[C:9]3[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][N:10]3[N:16]=2)[CH:5]=[N:4][CH:3]=1

Participants

3

Reactant 1

HCID 178426513HCID 178426513, compound

Product 1

HCID 82566418HCID 82566418, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
150 °C

Procedure

Lead tetra acetate (2.28 g, 0.0051 mol) was added to a solution of 5-bromo-N-(5-methylpyridin-2-yl)nicotinimidamide (44-1; 1 g, crude 0.0034 mol) in toluene (40 mL) in a 80 mL microwave vial at RT. The reaction mixture was heated to 150° C. for 2.5 h under microwave irradiation. It was concentrated under vacuum to afford the crude product, which was purified by silica gel column chromatography to afford the title compound. MS (M+1): 290.1

Workup

  1. customat RT
  2. concentrationIt was concentrated under vacuum
  3. customto afford the crude product, which
  4. customwas purified by silica gel column chromatography

Sources & evidence

ORD record
ord-b2ad48de1d2c4460952f4a11f894fedd
Source dataset
uspto-grants-2015_11
Patent number
US09193724B2

Reaction notes

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