Ethyl 3-(3-methyl-3-(4-octylphenyl)ureido)propanoate → 3-(3-Methyl-3-(4-octylphenyl)ureido)propanoic acid
Reaction equation
[CH3:1][N:2]([C:13]1[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[CH:15][CH:14]=1)[C:3](=[O:12])[NH:4][CH2:5][CH2:6][C:7]([O:9]CC)=[O:8].C(C1C=CC(NC(=O)NCCC(OCC)=O)=CC=1)CCCCCCC>>[CH3:1][N:2]([C:13]1[CH:14]=[CH:15][C:16]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])=[CH:17][CH:18]=1)[C:3](=[O:12])[NH:4][CH2:5][CH2:6][C:7]([OH:9])=[O:8]Participants
3
Procedure
When the product of Step C is substituted for ethyl 3-(3-(4-octylphenyl)ureido)propanoate in Example 11, Step B, the identical process afforded the title compound in 84% yield, as a colourless solid. 1H-NMR (CDCl3) 7.19 (d, 2H, J=8.3 Hz); 7.09 (d, 2H, J=8.3 Hz); 4.83 (m, 1H); 3.54 (m, 2H); 3.4 (m, 2H); 3.22 (s, 3H); 2.6-2.5 (m, 4H); 1.59 (m, 2H); 1.27 (m, 10H); 0.86 (t, 3H, J=7 Hz).
Sources & evidence
- ORD record
- ord-60cd7f051e8547fc9cbecc586b4fba15
- Source dataset
- uspto-grants-2015_11
- Patent number
- US09193716B2
Reaction notes
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