Ethyl 3-(3-(4-octylphenyl)ureido)propanoate → HCID 66614924, compound

HRID 717637Notes

Reaction equation

HRID 717637 reaction equation
[CH2:1]([C:9]1[CH:26]=[CH:25][C:12]([CH2:13][N:14]([C:16]([NH:18][CH2:19][C:20]([O:22]CC)=[O:21])=[O:17])[NH2:15])=[CH:11][CH:10]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].C(C1C=CC(NC(=O)NCCC(OCC)=O)=CC=1)CCCCCCC>>[CH2:1]([C:9]1[CH:26]=[CH:25][C:12]([CH2:13][N:14]([C:16]([NH:18][CH2:19][C:20]([OH:22])=[O:21])=[O:17])[NH2:15])=[CH:11][CH:10]=1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

3

Reactant 2

HCID 66615004Ethyl 3-(3-(4-octylphenyl)ureido)propanoateHCID 66615021HCID 66615021, compound

Product 1

HCID 66614924HCID 66614924, compoundYield 78%

Procedure

When the product of Step D is substituted for ethyl 3-(3-(4-octylphenyl)ureido)propanoate in Example 11, Step B, the identical process afforded the title compound in 78% yield, as a colourless solid. 1H-NMR (CDCl3) 7.15 (m, 4H); 6.91 (t, 1H, J=5.7 Hz); 4.66 (s, 2H); 4.02 (d, 2H, J=5.7 Hz); 3.56 (bs, 3H); 2.57 (t, 2H, J=7.9 Hz); 1.58 (m, 2H); 1.26 (m, 10H); 0.86 (t, 3H, J=7 Hz).

Sources & evidence

ORD record
ord-d708f43ae26c4b31b633a4a60a351250
Source dataset
uspto-grants-2015_11
Patent number
US09193716B2

Reaction notes

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