反应详情

A mixture of the product of Step B (0.16 g; 0.41 mmol), 1-octyne (0.073 ml; 0.49 mmol), Cl2Pd(PPh3)2 (0.02 g; 0.028 mmol) and CuI (0.005 g; 0.026 mmol) was degassed under reduced pressure and saturated with dry N2. After addition of DIPEA (0.5 ml), the resulting mixture was stirred for 2 h at room temperature under N2. The solvents were removed in vacuo and the residue was diluted to 15 ml with EtOAc and washed with 5% citric acid, 5% NaHCO3, H2O, brine and dried over anhydrous MgSO4 and filtered. The filtrate was evaporated to dryness under reduced pressure and the residue was purified by FCC (SiO2; CH2Cl2) to give the title compound (0.1 g; 65%) as a brownish solid. 1H-NMR (CDCl3) 7.75 (d, 1H, J=8.4 Hz); 7.16 (d, 1H, J=8.4 Hz); 7.1 (s, 1H); 5.34 (1, 1H, J=5.8 Hz); 4.11 (q, 2H, J=7.1 Hz); 3.82 (t, 2H, J=8.8 Hz); 3.52 (m, 2H); 3.06 (t, 2H, J=8.8 Hz); 2.56 (t, 2H, J=5.8 Hz); 2.33 (t, 2H, J=7.1 Hz); 1.53 (m, 2H); 1.52 (m, 2H); 1.26 (m, 6H); 1.23 (t, 2H, J=7.1 Hz); 0.86 (1, 3H, J=6.9 Hz).

1. customwas degassed under reduced pressure and saturated with dry N2
2. additionAfter addition of DIPEA (0.5 ml)
3. customThe solvents were removed in vacuo
4. additionthe residue was diluted to 15 ml with EtOAc
5. washwashed with 5% citric acid, 5% NaHCO3, H2O, brine
6. dry with materialdried over anhydrous MgSO4
7. filtrationfiltered
8. customThe filtrate was evaporated to dryness under reduced pressure
9. customthe residue was purified by FCC (SiO2; CH2Cl2)