HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzaldehyde → N-(4-Bromobenzyl)-4-fluoro-N-isopropylbenzenamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzaldehyde | HCID 240 | — |
| Reactant | Glycine, N-methyl-, hydrochloride (1:1) | HCID 69483 | — |
| Reactant | 4-Bromobenzaldehyde | HCID 70741 | — |
| Reactant | Benzenamine, 4-fluoro-N-(1-methylethyl)- | HCID 154403 | — |
| Product | N-(4-Bromobenzyl)-4-fluoro-N-isopropylbenzenamine | HCID 66614972 | 93% |
Reaction Steps
When the product of Step A and 4-bromobenzaldehyde were substituted for sarcosine hydrochloride salt and 4-(5-(((4-fluorophenyl)) isopropyl)amino)methyl)thiophen-2-yl)benzaldehyde, respectively, in Example 22, Step C, the similar process afforded the title compound in 93% yield, as a pale paste. 1H-NMR (CDCl3) 7.39 (d, 2H, J=8.18 Hz); 7.14 (d, 2H, J=8.08 Hz); 6.91-6.81 (m, 2H); 6.62-6.57 (m, 2H); 4.26 (s, 2H); 4.11-4.04 (m, 1H); 1.18 (d, 2H, J=5.34 Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193716B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-5b437486579f40099c7793c29f5c5414 |
| Source note | uspto-grants-2015_11 |