HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromobenzaldehyde → 4'-But-2-ynoylbiphenyl-4-carbaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromobenzaldehyde | HCID 70741 | — |
| Reactant | 5-Hydroxymethylthiophene-2-boronic acid | HCID 4374265 | — |
| Reactant | 1-(4-Bromophenyl)but-2-yn-1-one | HCID 66615071 | — |
| Product | 4'-But-2-ynoylbiphenyl-4-carbaldehyde | HCID 86660616 | 58% |
Reaction Steps
When the product of Step A and 4-carbaldehyde-boronic acid were substituted for 4-bromobenzaldehyde and 5-(hydroxymethyl)thiophen-2-ylboronic acid, respectively, in Example 22, Step A, the similar procedure afforded the title compound in 58% yield, as a creamy gum. 1H-NMR (CDCl3) 10.07 (s, 1H); 8.23 (d, 2H, J=8.4 Hz); 7.98 (d, 2H, J=8.4 Hz); 7.78 (d, 2H, J=8.24 Hz); 7.72 (d, 2H, J=8.54 Hz); 2.18 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193716B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-99b60aa90a9a4ff8b8a60efbb5cbd651 |
| Source note | uspto-grants-2015_11 |