HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl-1-(4-((5-chlorobenzofuran-3-yl)methoxy)benzyl)azetidine-3-carboxylate → 1-[[4-[4-[3-[3-(Trifluoromethyl)phenyl]but-2-enoyl]phenyl]phenyl]methyl]azetidine-3-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl-1-(4-((5-chlorobenzofuran-3-yl)methoxy)benzyl)azetidine-3-carboxylate | HCID 66614996 | — |
| Reactant | Methyl-1-((4'-(3-(3-(trifluoromethyl)phenyl)but-2-enoyl)biphenyl-4-yl)methyl)azetidine-3-carboxylate | HCID 68002037 | — |
| Product | 1-[[4-[4-[3-[3-(Trifluoromethyl)phenyl]but-2-enoyl]phenyl]phenyl]methyl]azetidine-3-carboxylic acid | HCID 66615049 | 62% |
Reaction Steps
When the product of Step E was substituted for methyl-1-(4-((5-chlorobenzofuran-3-yl)methoxy)benzyl)azetidine-3-carboxylate in Example 25, Step E, the similar process afforded the title compound in 62% yield, as a light yellow solid. 1H-NMR (CDCl3+CD3OD) 7.84 (d, 2H, J=8.34 Hz); 7.59-7.33 (m, 6H); 4.7 (d, 2H); 3.96-3.92 (m, 4H); 3.19-3.14 (m, 1H); 2.36 (s, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09193716B2 |
| Source dataset | uspto-grants-2015_11 |
| ORD ID | ord-78f5768646dc4f32af7557f69bed6d26 |
| Source note | uspto-grants-2015_11 |