反应详情

{(3-{tert-Butoxycarbonyl-[4-(7-oxo-1,7-dihydro-imidazo[1,2-a]pyrimidin-6-yl)-benzyl]-amino}-propyl)-carbamic acid tert-butyl ester (48 mg, 0.097 mmol) was dissolved in CH2Cl2 (5 mL), TFA (1 mL) was added and stirred at room temperature for 2 h. The reaction mixture was concentrated and 3 mL of 0.6 N HCl and 2 mL of acetonitrile were added and stirred for 0.5 h, concentrated to a ca. 3 mL and lyophilized to give the title compound (35 mg, 100%). 1NMR (300 MHz, CD3OD): δ 8.90 (s, 1H), 7.79 (s, 1H), 7.77 (d, J=8.2 Hz, 2H), 7.70 (d, J=8.2 Hz, 2H), 7.67 (s, 1H), 4.33 (s, 2H), 3.23 (t, J=8.1 Hz, 2H), 3.06 (t, J=7.5 Hz, 2H), 2.15 (m, 2H). LCMS (EI) m/z: 297.1 (M+H+).

1. concentrationThe reaction mixture was concentrated
2. addition3 mL of 0.6 N HCl and 2 mL of acetonitrile were added
3. stirringstirred for 0.5 h
4. concentrationconcentrated to a ca. 3 mL