反应详情

{4-[2-(4-Bromo-phenyl)-7-oxo-1,7-dihydro-imidazo[1,2-a]pyrimidin-6-yl]-benzyl}-(3-tert-butoxycarbonylamino-propyl)-carbamic acid tert-butyl ester (100 mg, 0.153 mmol) was dissolved in CH2Cl2 (5 mL), TFA (1 mL) was added and stirred at room temperature for 2 h. The reaction mixture was concentrated and 3 mL of 0.6 N HCl and 2 mL of acetonitrile were added and stirred for 0.5 h, concentrated to a ca. 3 mL and lyophilized to give the title compound (80 mg, 100%). 1NMR (300 MHz, CD3OD): δ 8.99 (s, 1H), 8.24 (s, 1H), 7.75 (m, 8H), 4.30 (s, 2H), 3.32 (t, J=8.1 Hz, 2H), 3.09 (t, J=7.5 Hz, 2H), 2.17 (m, 2H). LCMS (EI) m/z: 454 (M+H+).

1. concentrationThe reaction mixture was concentrated
2. addition3 mL of 0.6 N HCl and 2 mL of acetonitrile were added
3. stirringstirred for 0.5 h
4. concentrationconcentrated to a ca. 3 mL