HCID 67373307, compound → HCID 67371330, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-(5-methyl-2-nitrophenyl)-2-(6-methylpyridin-3-yl)propanenitrile (0.3 g, 0.00106 mol), 10% palladium carbon (0.180 g) in THF (1 mL) and MeOH (6 mL) was stirred under atmospheric hydrogen pressure at 40° C. for 24 h. After completion of reaction (monitored by TLC), catalyst was removed by filtration through Celite, and the filtrate concentrated under reduced pressure. The product was purified by column chromatography (25% EtOAc:hexane in silica 100-200 mesh, diameter of column—5.0 cm, height of silica—approx. 5 inch) to give the desired compound as a yellow colored solid (0.075 g, 30% yield).

Provenance & Evidence