7-Methyl-3,4-dihydro-2H-1,4-benzoxazine → HCID 86691924, compound

Participants

Reaction Steps

3,4-Dihydro-7-methyl-2H-benzo[b][1,4]oxazine (280 mg, 1.87 mmol) was dissolved in 3N HCl (20 mL). Sodium nitrite (129 mg, 1.87 mmol) in water (1 mL) was added dropwise into the reaction mixture at 0° C. The reaction mixture was stirred for 2 h at RT. The reaction mixture was diluted with water (20 mL) and extracted with EtOAc. The organic layer was dried over sodium sulfate and concentrated under vacuum to obtain 270 mg of 7-Methyl-4-nitroso-3,4-dihydro-2H-benzo[1,4]oxazine (free base).

Provenance & Evidence