HCID 10081720, compound → HCID 67378758, compound

Participants

Reaction Steps

3-(Pyridin-4-yl)quinoline (1 g, 0.00485 mol) was dissolved in ethanol (30 mL). To this was added platinum oxide (0.4 g) under nitrogen atmosphere, and the reaction mixture was hydrogenated at 50 psi for 10 h. After completion of reaction (monitored by TLC), the catalyst was removed by filtration, the filtrate concentrated under reduced pressure and the residue purified by column chromatography (30% EtOAc:hexane on silica 100-200 mesh, diameter of column—2.5 cm, height of silica—approx. 5 inch) to provide the desired compound (0.4 g, 40% yield).

Provenance & Evidence