反应详情

温度

0 °C

1-Nitroso-1,2,3,4-tetrahydroquinoline (5.8 g, 0.0357 mol) was dissolved in acetic acid (50 mL). NH-piperidone (7.97 g, 0.0464 mol) was added and cooled to 0° C. Zinc dust was added (11.67 g, 0.1785 mol) in small portions. After addition, the reaction mixture was heated at 85° C. for 1 h. The reaction was monitored by TLC & LCMS. After completion of reaction, the mixture was filtered and the filtrate neutralized by aq. NaHCO3. The mixture was extracted with EtOAc (3×200 mL). The organic layer was dried over sodium sulfate and concentrated under reduced pressure to obtain 6.2 g product that was purified by column chromatography using 100-200 mesh silica and 5-7% MeOH in DCM+2 drops NH4OH to give pure product.

1. additionAfter addition
2. temperaturethe reaction mixture was heated at 85° C. for 1 h
3. customAfter completion of reaction
4. filtrationthe mixture was filtered
5. extractionThe mixture was extracted with EtOAc (3×200 mL)
6. dry with materialThe organic layer was dried over sodium sulfate
7. concentrationconcentrated under reduced pressure