D-Psicose → HCID 24267036, compound

Participants

Reaction Steps

3-(4-Fluorophenyl) quinoline (1 g, 0.00448 mol) was dissolved in ethanol (25 mL), and to this was added platinum oxide (0.4 g) under nitrogen atmosphere. The reaction mixture was hydrogenated at 45 Psi for 10 h. After completion of reaction (monitored by TLC), the catalyst was removed by filtration, and the filtrate concentrated under reduced pressure. The crude product was purified by column chromatography (silica 100-200 mesh, diameter of column—2.5 cm, height of silica—approx. 5 inch) to provide the desired compound (0.25 g, 25% yield).

Provenance & Evidence