HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 717818Generated: November 1, 2026
Formic Acid → Methyl 5-chloro-2-(3-fluorophenyl)-6-[(formylamino)methyl]nicotinate
https://huagongshe.com/reaction/717818
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Formic Acid | HCID 284 | — |
| Reactant | Methyl 6-(aminomethyl)-5-chloro-2-(3-fluorophenyl)nicotinate | HCID 58515976 | — |
| Product | Methyl 5-chloro-2-(3-fluorophenyl)-6-[(formylamino)methyl]nicotinate | HCID 58515924 | — |
Reaction Steps
Methyl 6-(aminomethyl)-5-chloro-2-(3-fluorophenyl)nicotinate (1.1 g, 3.7 mmol) was stirred in formic acid (10 mL) and heated to 90° C. for 10 hours. Evaporation gave the crude material which was contaminated with the corresponding dechlorinated byproduct (1.1 g, quantitative). LCMS calculated for C15H13ClFN2O3 (M+H)+: m/z=323.1. found: 322.9.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09193721B2 |
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| Source dataset | uspto-grants-2015_11 |
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| ORD ID | ord-4d9d436cc8cd400e9d781a09a9ec1422 |
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| Source note | uspto-grants-2015_11 |
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