Chlorosuccinimide → HCID 58515969, compound

Participants

Reaction Steps

tert-Butyl 4-{6-[(formylamino)methyl]-3-(methoxycarbonyl)pyridin-2-yl}piperazine-1-carboxylate (4.85 g, 0.0128 mol) and N-chlorosuccinimide (2.1 g, 15 mmol) was stirred in tetrahydrofuran (85 mL) at 50° C. for 16 hours. Evaporation and purification on silica gel using ethyl acetate in hexanes (0-80%) gave the desired compound (5.6 g, 100%). LCMS calculated for C18H26ClN4O5 (M+H)+: m/z=413.2. found: 412.9.

Provenance & Evidence