Phosphorus oxychloride → HCID 66992789, compound

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Reaction Steps

A solution of tert-butyl 4-{5-chloro-6-[(formylamino)methyl]-3-(methoxycarbonyl)pyridin-2-yl}piperazine-1-carboxylate (670 mg, 2.2 mmol) in phosphoryl chloride (5.0 mL, 54 mmol) was heated to 70° C. for 30 minutes. Evaporation gave the desired compound (700 mg, 98%). LCMS calculated for C13H16ClN4O2 (M+H)+: m/z=295.1. found: 294.9.

Provenance & Evidence