Water → HCID 58515946, compound

Participants

Reaction Steps

Methyl 5-[4-(tert-butoxycarbonyl)piperazin-1-yl]-8-chloroimidazo[1,5-a]pyridine-6-carboxylate (120 mg, 0.3123 mmol) was stirred in methanol (2 mL) and 3.0 M sodium hydroxide in water (0.4 mL, 1.0 mmol) was added. The mixture was stirred at room temperature overnight. Acidification with a few drops of 1 M HCl (checked with litmus paper pH 6), evaporation and trituration with water gave the desired compound (94 mg, 79%). LCMS calculated for C17H22ClN4O4 (M+H)+: m/z=381.1. found: 380.9.

Provenance & Evidence