HCID 58515929, compound → HCID 178473887, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-[5-(4-acetylpiperazin-1-yl)-8-chloroimidazo[1,5-a]pyridin-6-yl]ethanamine (11.2 mg, 0.035 mmol), 6-bromo-9H-purine (14 mg, 0.070 mmol) and IV, N-diisopropylethylamine (18 μL, 0.10 mmol) in ethanol (0.93 mL) was heated to 110° C. overnight. Purification by preparative LCMS (pH 10) gave the desired compound (6.7 mg, 44%). LCMS calculated for C20H23ClN9O (M+H)+: m/z=440.2. found: 439.9. 1H NMR (300 MHz, DMSO-d6): δ 8.52 (s, 1H), 8.17 (m, 3H), 7.42 (s, 1H), 7.37 (s, 1H), 5.90 (s, 1H), 3.80 (m, 2H), 3.65 (m, 2H), 3.50 (m, 1H), 3.40 (m, 2H), 3.20 (m, 2H), 2.09 (s, 3H), 1.52, (m, 3H).

Provenance & Evidence