Hydrochloric Acid → HCID 178463546, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-{4-[6-(1-aminoethyl)-8-chloroimidazo[1,5-a]pyridine-5-yl}piperazin-1-yl]-3-oxopropanenitrile (18 mg, 0.052 mmol), 6-bromo-9-(tetrahydro-2H-pyran-2-yl)-9H-purine (29 mg, 0.10 mmol) and N,N-diisopropylethylamine (27 μL, 0.16 mmol) in ethanol (1.0 mL) was heated at 110° C. overnight. The mixture was evaporated and a 4 M solution of hydrogen chloride in 1,4-dioxane (1.0 mL, 4.0 mmol) was added. The mixture was evaporated and a 4 M solution of hydrogen chloride in 1,4-dioxane (1.0 mL, 4.0 mmol) was added. The mixture was evaporated and purified by preparative LCMS (pH 10) to give the desired compound (8.6 mg, 36%). LCMS calculated for C21H22ClN10O (M+H)+: m/z=465.2. found: 464.9.

Provenance & Evidence